Coloxan WS

Doxycycline & Colistin water-soluble powder

Powder for oral administration

  • Composition
  • Contains per gram powder:
  • Doxycycline hyclate
    100 mg.
  • Colistin sulphate
    1200000 IU.
  • Excipients ad
    1 g.

Description

Doxycycline belongs to the group of tetracyclines and acts bacteriostatic against many Gram-positive and Gram-negative bacteria like Bordetella, Campylobacter, E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. Doxycycline is also active against Chlamydia, Mycoplasma and Rickettsia spp. The action of doxycycline is based on inhibition of bacterial protein synthesis. Doxycycline has good affinity towards the lungs and is
therefore especially useful for treatment of bacterial respiratory infections. Colistin is an antibiotic from the group of polymyxins with bactericidal action against mainly Gram-negative bacteria like E. coli, Haemophilus and Salmonella spp. Polymyxins interact strongly with phospholipids and penetrate into and disrupt the structure of cell membranes. Administered orally, colistin is poorly resorbed and, therefore, performs its action predominantly gastrointestinally.

Indications

Gastrointestinal and respiratory infections caused by micro-organisms sensitive to doxycycline and/or colistin like Bordetella, Campylobacter, Chlamydia, E. coli, Klebsiella, Haemophilus, Mycoplasma, Pasteurella, Rickettsia, Salmonella, Staphylococcus and Streptococcus spp. in calves, goats, poultry, sheep and swine.

Contra indications

Hypersensitivity to tetracyclines and/or polymyxins.
Administration to animals with seriously impaired renal and/or hepatic functions, animals with an active microbial digestion or animals producing milk or eggs for human consumption.
Concurrent administration of penicillins, cephalosporins, quinolones and cycloserine.

Side effects

Discoloration of teeth in young animals or hypersensitivity reactions may occur. Digestive alterations may appear, such as intestinal dysbiosis, accumulation of gases or mild diarrhoea.

Dosage

For oral administration.

 

Calves, goats and sheep:
Twice daily 1 g per 20 kg body weight for 4 - 5 days.

 

Poultry:
1 kg per 2000 litres of drinking water for 4 - 5 days.

 

Swine:
1 kg per 1000 litres of drinking water for 4 - 5 days.

 

Note: for pre-ruminant calves, lambs and kids only. Doxycol WS is not for use in animals from which milk or eggs are produced for human consumption.

Withdrawal times

- For meat:
Calves, goats and sheep : 14 days.
Swine : 8 days.
Poultry : 7 days.

Packaging

Sachet of 100 g and jar of 1000 g.

Product Code:

WDC