The combination of procaine penicillin G and neomycin acts additive and in some cases synergistic. Procaine penicillin G is a narrow-spectrum penicillin with bactericidal action against mainly Gram-positive bacteria like Corynebacterium, Listeria, Clostridium, Erysipelothrix, Streptococcus and Staphylococcus spp. It acts by inhibition of bacterial cell wall synthesis in actively growing bacteria. Neomycin is an aminoglycoside with bactericidal action against mainly Gram-negative bacteria like E. coli, Klebsiella, Salmonella and Pasteurella spp. Its action is based on inhibition of bacterial protein synthesis.
Pen-N is indicated for the therapeutic treatment of arthritis and mastitis and for the therapeutic treatment of gastrointestinal, respiratory and urinary tract infections caused by penicillin and neomycin sensitive micro-organisms, like Campylobacter, Clostridium, Corynebacterium, E. Coli, Erysipelothrix, Haemophilus, Klebsiella, Listeria, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp., in calves, cattle, sheep and swine.
Hypersensitivity to penicillin and/or aminoglycosides.
Administration to animals with an impaired renal function.
Concurrent administration of nephrotoxic substances or anaesthetics.
Occasionally in sucking and fattening pigs, administration of this product may cause a transient pyrexia, vomiting, shivering, listlessness and incoordination. Additionally in pregnant sows and gilts, a vulval discharge, which could be associated with abortion, has been reported.
Ototoxicity and nephrotoxicity.
Shake well before use. For intramuscular administration.
The general dosage rate is 1 ml per 20 kg bodyweight, daily, for 3 days.
Do not administer more than 20 ml in cattle, more than 10 ml in swine or more than 5 ml in calves and sheep per injection site.
Meat and offal:
- Calves and cattle: 89 days.
- Swine: 50 days.
- Sheep: 62 days.
- Cattle: 5 days.
Not for use in sheep producing milk for human consumption.