The combination of trimethoprim and sulfadoxine acts synergistic and usually bactericidal against many Gram-positive and Gram-negative bacteria like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. Both compounds affect bacterial purine synthesis in a different way, as a result, of which a double blockade is accomplished.
Gastrointestinal, respiratory and urinary tract infections caused by trimethoprim and sulfadoxine sensitive bacteria, like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. in calves, cattle, goats, sheep and swine.
Hypersensitivity to trimethoprim and/or sulfonamides.
Administration to animals with a seriously impaired renal and/or hepatic function or with blood dyscrasias.
Anaemia, leucopenia and thrombocytopenia.
General: 1 ml per 10 - 15 kg body weight for 3 - 5 days.
- For meat : 10 days.
- For milk : 3 days.