The combination of trimethoprim and sulfadiazine acts synergistic and usually bactericidal against many Gram-positive and Gram-negative bacteria like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. Both compounds affect bacterial purine synthesis in a different way, as a result of which a double blockade is accomplished.
Gastrointestinal and respiratory infections caused by trimethoprim and sulfadiazine sensitive micro-organisms like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. in calves, sheep, goats, poultry and swine.
Hypersensitivity to trimethoprim and/or sulphonamides.
Administration to animals with a seriously impaired renal and/or hepatic function or with blood dyscrasias.
After long-term treatment and high dosages crystalluria can occur.
When symptoms of crystalluria occur (haematuria, kidney colic), treatment has to be stopped immediately and for example sodium carbonate (alkalinises) has to be administered for increasing urine solubility of sulfadiazine.
Administration for a prolonged period also increases the risk for blood dyscrasias. Anaemia, leucopenia and thrombocytopenia may also occur.
For oral administration:
Calves, goats and sheep:
Twice daily 5 g per 100 kg body weight for 4 - 7 days.
Poultry and swine:
1 kg per 1500 - 2500 litres of drinking water for 4 - 7 days.
Note: for pre-ruminant calves, lambs and kids only.
- For meat:
Calves, sheep, goats and swine: 8 days.
Poultry: 5 days.