The combination of lincomycin and spectinomycin acts additive and in some cases synergistic.
Spectinomycin acts bacteriostatic or bactericidal, depending on the dose, against mainly Gram-negative bacteria like Campylobacter, E. coli and Salmonella spp. Lincomycin acts bacteriostatic against mainly Gram-positive bacteria like Mycoplasma, Treponema, Staphylococcus and Streptococcus spp. Cross-resistance of lincomycin with macrolides can occur.
Gastrointestinal and respiratory infections caused by lincomycin and spectinomycin sensitive micro-organisms, like Campylobacter, E. coli, Mycoplasma, Salmonella, Staphylococcus, Streptococcus and Treponema spp. in calves, cats, dogs, goats, sheep and swine.
Hypersensitivity to lincomycin and/or spectinomycin.
Administration to animals with an impaired renal and/or hepatic function.
Concurrent administration of penicillins, cephalosporins, quinolones and cycloserine.
Shortly after injection a slight pain, itching or diarrhoea can occur.
For intramuscular administration:
1 ml per 10 kg body weight for 4 days.
Goats and sheep:
1 ml per 10 kg body weight for 3 days.
1 ml per 10 kg body weight for 3 - 7 days.
Cats and dogs:
1 ml per 5 kg body weight for 3 - 5 days, with a maximum of 21 days.
- For meat:
Calves, goats, sheep and swine : 14 days.
- For milk : 3 days.