The combination of lincomycin and spectinomycin acts is additive and in some cases synergistic.
Spectinomycin acts mainly against Mycoplasma spp. and Gram-negative bacteria like E. coli and Pasteurella and Salmonella spp. Lincomycin acts mainly against Mycoplasma spp., Treponema spp., Campylobacter spp. and Gram-positive bacteria like Staphylococcus, Streptococcus, Corynebacterium spp. and Erysipelothrix rhusiopathiae. Cross-resistance of lincomycin with macrolides may occur.
Gastrointestinal and respiratory infections caused by micro-organisms sensitive to spectinomycin and lincomycin, such as Campylobacter, E. coli, Mycoplasma, Salmonella, Staphylococcus, Streptococcus and Treponema spp. in poultry and swine, most notably:
Poultry : Prevention and treatment of chronic respiratory disease (CRD) associated with mycoplasma and coliform infections of growing poultry susceptible to the action of the antibiotic combination.
Pigs : Treatment of enteritis caused by Lawsonia intracellularis (ileitis).
Do not use in poultry producing eggs for human consumption.
Do not use in horses, ruminating animals, guinea pigs and rabbits.
Do not use in animals known to be hypersensitive to the active ingredients.
Do not co-administer with penicillins, cephalosporins, quinolones and/or cycloserine.
Do not administer to animals with seriously impaired renal functions.
For oral administration:
150 g per 200 litres of drinking water for 5 - 7 days.
150 g per 1500 litres of drinking water for 7 days.
Note: Do not use in poultry producing eggs for human consumption.
- For meat:
Swine : 0 days.
Poultry : 5 days.