The combination of colistin and trimethoprim acts additive. Colistin is an antibiotic from the group of polymyxins with a bactericidal action against Gram-negative bacteria like E. coli, Haemophilus and Salmonella spp. Since colistin is absorbed for a very small part after oral administration only gastrointestinal indications are relevant. Trimethoprim is an antibacterial agent with a bacteriostatic action against many Gram-negative and Gram-positive bacteria like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. After oral administration trimethoprim is absorbed almost totally and penetrates well into tissues and cells.
Gastrointestinal infections caused by colistin and trimethoprim sensitive micro-organisms, like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. in kids, lambs and piglets.
Hypersensitivity to colistin and/or trimethoprim.
Administration to animals with a seriously impaired renal function.
Renal dysfunction, neurotoxicity and neuromuscular blockade.
For oral administration:
Kids and lambs : Twice daily 1 dose per 2.5 - 3 kg body weight for 3 days.
Piglets (1 - 3 kg) : Daily 1 dose, for 3 days.
Piglets (3 - 5 kg) : Twice daily 1 dose for 3 days.
Each press on the dosing pump delivers one dose, i.e. 1 ml.
- For meat: 7 days.