The combination of amoxycillin and gentamicin acts synergistically against a wide range of infections caused by both Gram-positive (e.g. Staphylococcus, Streptococcus and Corynebacterium spp.) and Gram-negative (e.g. E.coli, Pasteurella, Salmonella and Pseudomonas spp.) bacteria in cattle and swine. Amoxycillin inhibits mainly in Gram-positive bacteria the cross-linkage between the linear peptidoglycan polymer chains that make up a major component
of the cell wall. Gentamicin binds to the 30S subunit of the ribosome of mainly Gram-negative bacteria, thereby interrupting protein synthesis.
gastrointestinal, respiratory and intramammary infections caused by bacteria sensitive to the combination of amoxicillin and gentamicin, such as pneumonia, diarrhoea, bacterial enteritis, mastitis, metritis and cutaneous abscesses.
respiratory and gastrointestinal infections caused by bacteria sensitive to the combination of amoxicillin and gentamicin, such as pneumonia, colibacillosis, diarrhoea, bacterial enteritis and mastitis-metritis-agalactia syndrome (MMA).
Hypersensitivity towards amoxycillin and/or gentamicin.
Administration to animals with a seriously impaired hepatic and/or renal function.
Concurrent administration of tetracyclines, chloramphenicol, macrolides and lincosamides.
Concurrent administration of nephrotoxic and/or ototoxic preparations, intravenous calcium supplementation, iron supplementation and non-steroidal antiinflammatory preparations.
For intramuscular administration. The general dosage is 1 ml per 10 kg body weight per day for 3 days.
30 - 40 ml per animal per day for 3 days.
10 - 15 ml per animal per day for 3 days.
5 - 10 ml per animal per day for 3 days.
1 - 5 ml per animal per day for 3 days.
Shake well before use. Do not administer more than 20 ml in cattle or more than 10 ml in swine and more than 5 ml in calves per injection site to favour absorption and dispersion.
- For meat : 30 days.
- For milk : 2 days.