The combination of tylosin and doxycycline acts additive. Doxycycline belongs to the group of tetracyclines and acts bacteriostatic against many Gram-positive and Gram-negative bacteria like Bordetella, Campylobacter, E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. Doxycycline is also active against Chlamydia, Mycoplasma and Rickettsia spp. The action of doxycycline is based on inhibition of bacterial protein synthesis. Doxycycline has a great affinity to the lungs and is therefore especially useful for treatment of bacterial respiratory infections. Tylosin is a macrolide antibiotic with a bacteriostatic action against Gram-positive and
Gram-negative bacteria like Campylobacter, Pasteurella, Staphylococcus, Streptococcus and Treponema spp. and Mycoplasma.
Gastrointestinal and respiratory infections caused by tylosin and doxycycline sensitive microorganisms, like Bordetella, Campylobacter, Chlamydia, E. coli, Haemophilus, Mycoplasma, Pasteurella, Rickettsia, Salmonella, Staphylococcus, Streptococcus and Treponema spp. in calves, goats, poultry, sheep and swine.
Hypersensitivity to tetracyclines and/or tylosin.
Administration to animals with a seriously impaired hepatic function.
Concurrent administration of penicillins, cephalosporins, quinolones and cycloserine.
Administration to animals with an active microbial digestion.
Discoloration of teeth in young animals.
Diarrhoea may occur.
For oral administration:
Calves, goats and sheep:
Twice daily 5 g per 100 kg body weight for 3 - 5 days.
Poultry and swine:
1 kg per 1000 - 2000 litres of drinking water for 3 - 5 days.
Note: for pre-ruminant calves, lambs and kids only.
- For meat:
Calves, goats and sheep : 14 days.
Swine : 8 days.
Poultry : 7 days.